منابع مشابه
miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6
Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators of metastasis that act by modulating their target genes. In this study, we found that miR-143 and miR-145 act via a common target gene, MYO6, to regulate the epithelial-mesenchymal transition (EMT) and inhibit metastasis. We determined t...
متن کاملARTICLES miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
MicroRNAs (miRNAs) are regulators of myriad cellular events, but evidence for a single miRNA that can efficiently differentiate multipotent stem cells into a specific lineage or regulate direct reprogramming of cells into an alternative cell fate has been elusive. Here we show that miR-145 and miR-143 are co-transcribed in multipotent murine cardiac progenitors before becoming localized to smoo...
متن کاملMicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer
The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). The pathological features and clinical behaviors of synchronous CRC have been comprehensively described; however, the expression profile of miRNA and small nucleolar RNA (snoRNA) in synchronous CRC has not been elucidated. In the present study, the expression profile of miRNA and snoRNA in 5 syn...
متن کاملmiR-143 and miR-145 inhibit stem cell characteristics of PC-3 prostate cancer cells.
Emerging evidence demonstrates that cancer stem cells (CSCs) are the critical drivers of tumor progression and metastasis. The microRNAs (miRNAs) may play a crucial role in repressing/promoting metastasis of cancer by regulating CSCs. A previous study showed that miR-143 and miR-145 play an important role in regulating bone metastasis of prostate cancer (PCa), but the exact mechanism of regulat...
متن کاملMir 145/143: tumor suppressor, oncogenic microenvironmental factor or …both?
literature regarding the role of mir-143/145 in tumor initiation/progression. Herein, we aim to contribute our experience and observations to this ongoing debate. We will start from the experimental data presented in the outstanding work of the Tyler Jacks lab, by Dimitrova, Gocheva and colleagues [6]. They show, in a kRAS/p53 murine model of lung adenocarcinoma, that the contribution of the mi...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2011
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.110.958702